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AFB vaccine
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<blockquote data-quote="Dave Black" data-source="post: 11013" data-attributes="member: 200"><p>I’ve been thinking about how this might work (I still think it can’t – for beekeepers and AFB).</p><p></p><p>In the last 20 years there have been a few studies published about what has become known as ‘immune priming’ in invertebrates (in plants it’s called Systemic Acquired Resistance (SAR)). It is still the subject of debate, and how it happens hasn’t been explained, but it’s not contested that these studies have found in a variety of animals, including bumblebee bees (and worms, some fish, fruit flies, sponges, blah, blah…), a ‘memory’ of a pathological challenge can persist, and make the response better the next time it happens. It suggests another kind of adaptive immunity, besides antibody/lymphocyte/ T-cell ‘memory’ like ours.</p><p></p><p>There is also evidence of what is called ‘trans-generational’ immune priming, and it’s in honeybees, for AFB. (see Trans-generational immune priming in honeybees, 2014, <a href="https://doi.org/10.1098/rspb.2014.0454" target="_blank">Trans-generational immune priming in honeybees | Proceedings of the Royal Society B: Biological Sciences</a> ). To make it work you’ll have to feed your queen (not the hive) heat-killed <em>P. larvae</em> bacteria (not spores).</p><p></p><p>Anyway, just proof it’s important to keep learning and not take things for granted…</p></blockquote><p></p>
[QUOTE="Dave Black, post: 11013, member: 200"] I’ve been thinking about how this might work (I still think it can’t – for beekeepers and AFB). In the last 20 years there have been a few studies published about what has become known as ‘immune priming’ in invertebrates (in plants it’s called Systemic Acquired Resistance (SAR)). It is still the subject of debate, and how it happens hasn’t been explained, but it’s not contested that these studies have found in a variety of animals, including bumblebee bees (and worms, some fish, fruit flies, sponges, blah, blah…), a ‘memory’ of a pathological challenge can persist, and make the response better the next time it happens. It suggests another kind of adaptive immunity, besides antibody/lymphocyte/ T-cell ‘memory’ like ours. There is also evidence of what is called ‘trans-generational’ immune priming, and it’s in honeybees, for AFB. (see Trans-generational immune priming in honeybees, 2014, [URL="https://doi.org/10.1098/rspb.2014.0454"]Trans-generational immune priming in honeybees | Proceedings of the Royal Society B: Biological Sciences[/URL] ). To make it work you’ll have to feed your queen (not the hive) heat-killed [I]P. larvae[/I] bacteria (not spores). Anyway, just proof it’s important to keep learning and not take things for granted… [/QUOTE]
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